Elimination Reactions
poor nucleophiles in protic solvents catalyzed by acids
good nucleophiles in aprotic solvents
strong bases
strong sterically hindered bases
methyl
very slow or no reaction
S
N
2
S
N
2
S
N
2
primary
rearrangements
S
N
2
S
N
2
E2
primary hindered
rearrangements
S
N
2
E2
E2
secondary
S
N
1, E1 with heat (Saytzeff)
S
N
2
E2 (Saytzeff)
E2 (Hofmann)
tertiary
S
N
1, E1 with heat (Saytzeff)
S
N
1, E1 with heat (Saytzeff)
E2 (Saytzeff)
E2 (Hofmann)
Elimination Reactions
E1
E1cb
E2
Copyright © 2003 and beyond intergrader.net
Saturday, January 16, 2021 21:20
Elimination ReactionsElimination Reactions